We are glad to welcome you to the main page of the Laboratory of Gene Expression in Eukaryotes headed by Prof. Sergio Verjovski-Almeida. Our lab is located in a beautiful sunny city São Paulo, Brazil. Look through our website to find out more about us, our research (and other activities), open positions and publications.
Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis
In this article, we identified and characterized a long non-coding RNA INXS, transcribed from the opposite genomic strand of BCL-X. Ectopic INXS overexpression caused a shift in splicing toward BCL-XS isoform, activation of caspases, and led to apoptosis. In a mouse xenograft model, intra-tumor injections of an INXS-expressing plasmid caused a marked reduction in tumor weight. These data suggest that INXS is a strong candidate to be evaluated in cancer therapies.
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Estágio de Iniciação Científica ou Pós-graduação disponível. Mande e-mail ou telefone para obter mais informações.