Instituto de Química
USP, CATG, FAPESP Universidade de São Paulo CATG - Center for Advanced Technologies in Genomics FAPESP

Welcome!

We are glad to welcome you to the main page of the Laboratory of Gene Expression in Eukaryotes headed by Prof. Sergio Verjovski-Almeida. Our lab is located in a beautiful sunny city São Paulo, Brazil. Look through our website to find out more about us, our research (and other activities), open positions and publications.

Our most recent publication:

Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis





In this article, we identified and characterized a long non-coding RNA INXS, transcribed from the opposite genomic strand of BCL-X. Ectopic INXS overexpression caused a shift in splicing toward BCL-XS isoform, activation of caspases, and led to apoptosis. In a mouse xenograft model, intra-tumor injections of an INXS-expressing plasmid caused a marked reduction in tumor weight. These data suggest that INXS is a strong candidate to be evaluated in cancer therapies.

Nucleic Acids Research




Job openings

Positions open for undergraduate or graduate work. Send us an e-mail or call by phone for additional information.

Estágio de Iniciação Científica ou Pós-graduação disponível. Mande e-mail ou telefone para obter mais informações.